4.15.2018 | Andrew Lamberts

Benzodiazepine discontinuation is notoriously difficult; it is potentially life-threatening for individuals using regularly to discontinue use without tapering their dose over a period of weeks. There is an increased risk of hypertension, seizures, and death. [15 ] Drugs which lower the seizure threshold such as tramadol should be avoided during withdrawal.

Clonazepam has an intermediate onset of action, with a peak blood level occurring one to four hours after oral administration. Clonazepam has an elimination half-life of 18 – 50 hours to 19 – 60 hours, and is generally considered to be a long-acting benzodiazepine.

Clonazepam is a drug of the benzodiazepine class. This oxygen substitution at R 2 is shared with other benzodiazepine drugs with the suffix -azepam. Clonazepam also contains an oxygen group double bonded to R 2 of its diazepine ring to form a ketone. The benzyl ring of clonazepam is substituted at R 8 with a nitro group, NO 2 -. Further, the diazepine ring is bonded at R 5 to a 2-chlorinated phenyl ring. Benzodiazepine drugs contain a benzene ring fused to a diazepine ring, which is a seven membered ring with the two nitrogen constituents located at R 1 and R 4.

The anticonvulsant properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. [7 ].

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Additional experience reports can be found here:. There are currently no anecdotal reports which describe the effects of this compound within our experience index.

Clonazopam presents cross-tolerance with all benzodiazepines, meaning that after its consumption all benzodiazepines will have a reduced effect.


This legality section is a stub.

It is not a recommendation and should be verified with other sources for accuracy. DISCLAIMER : PW's dosage information is gathered from users and resources for educational purposes only.

It is strongly discouraged to combine these substances, particularly in common to heavy doses.

As such, it may contain incomplete or wrong information. You can help by expanding it.

[5 ]. It's worth noting that the sudden discontinuation of benzodiazepines can be potentially life-threatening for individuals using regularly for extended periods of time. [4 ] It is highly recommended to taper one's dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping abruptly.

Benzodiazepines increase the frequency in which the chlorine ion pore opens on the GABA A receptor while barbiturates increase the duration in which they are open, meaning when both are consumed, the ion pore will open more frequently and stay open longer [16 ]. This is particularly dangerous with other GABAergic depressants such as barbiturates and alcohol since they work in a similar fashion, but bind to distinct allosteric sites on the GABA A receptor, thus their effects potentiate one another. Benzodiazepine overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly and properly. Benzodiazepine overdose may occur when a benzodiazepine is taken in extremely heavy quantities or concurrently with other depressants.

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. The list below contains some common potentially dangerous combinations, but may not include all of them. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death. The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors.

[14 ] However, it is potentially lethal when mixed with depressants like alcohol or opioids. Clonazopam has a low toxicity relative to dose.

Death may occur when benzodiazepines are combined with other depressants such as opiates, barbiturates, gabapentinoids, alcohol or other GABAergic substances. [1 ].

After cessation, the tolerance returns to baseline in 7 - 14 days. Tolerance will develop to the sedative-hypnotic effects within a couple of days of continuous use. However, in certain cases this may take significantly longer in a manner which is proportional to the duration and intensity of one's long-term usage.

For more information on tapering from benzodiazepines in a controlled manner, please see this guide. Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction.

Symptoms of a benzodiazepine overdose may include severe thought deceleration, slurred speech, confusion, delusions, respiratory depression, coma or death. Benzodiazepine overdoses are sometimes treated with flumazenil, a GABA A antagonist [17 ], however care is primarily supportive in nature. Benzodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes.

It is strongly recommended that one use harm reduction practices when using this drug.

Clonazopam is extremely physically and psychologically addictive.

Benzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. [6 ] As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects ) of clonazepam on the nervous system.

[3 ] It is commonly used and FDA approved for the medical treatment of panic disorder, generalized anxiety disorder (GAD), and social anxiety disorder (SAD). Clonazepam [2 ] (trade name Klonopin ) is a long-acting psychoactive drug of the benzodiazepine class which produces anxiolytic, anticonvulsant, muscle relaxant, amnesic, sedative, depressant and hypnotic effects.